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65 Does the paradox that either GIPR agonist or antagonist exhibits benefits in combination with GLP-1R agonist correlates with the likely reduction of internalization, following the decrement of -arrestin recruitment or the acceleration of the dissociation rate (K off ) between the ligand and receptor, owing to competition between used agonists and antagonists in endogenous GIP

Endogenous GLP-1 released from the gut acts directly on vagal afferents, which relay information from the abdomen to the brain and regulate multiple physiological systems
Lancet 393 , 791846 (2019)

Upon triggering different diseases like insulin resistance (IR) or MI, it is possible to understand the role of DPP4 in these comorbidities of T2DM

Elderly patients with limited dexterity: Older adults with arthritis, neuropathy, or tremors may struggle with the fine motor skills needed for injection preparation and administration