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Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta

8 weeks (early titration): ~1 vial 16 weeks (up to 1.7 mg): ~2 vials 20+ weeks (2.4 mg maintenance): ~3 vials Insulin Syringes (U-100, 1 mL) Per week: 1 syringe (once-weekly dosing) 12 weeks: 12 syringes 24 weeks: 24 syringes 48 weeks: 48 syringes Bacteriostatic Water (10 mL bottles) Use 3.0 mL per vial for reconstitution

The data reveal some expected and unexpected patterns

Many people dont realize mild dehydration contributes significantly to constipation

Kahles F, Liberman A, Halim C, Rau M, Mollmann J, Mertens RW, Ruckbeil M, Diepolder I, Walla B, Diebold S, et al