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DPP-4 inhibitors degrade certain entero-hormones (e.g., glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1)), or incretins, which are primarily produced within minutes [9]

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Likewise, the PCE of retatrutide were blocked by 1 M (-)-N 6 -phenylisopropyladenosine (PIA), an A 1 -adenosine receptor agonist, and this effect was reversed by 1 M DPCPX, an adenosine A 1 -receptor antagonist