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Participants, investigators, and study staff involved in clinical conduct and outcome assessment were blinded to treatment allocation

DozioEVianelloEMalavazosAETacchiniLSchmitzGIacobellisGet alEpicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: a target to modulate cardiovascular risk

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In contrast, in human clinical trials with semaglutide or tirzepatide, about 60% of patients achieve a 20% reduction in weight and can keep that weight off with continued use