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In other words, they reduce the exaggerated salience
STEP 1 clinical trials published in the New England Journal of Medicine showed that semaglutide 2.4mg led to 14.9% reduction in body weight

This is like patients who tend to lose significant weight early on during a diet or vigorous exercise program

10.3390/antiox10020197

Sabbah E, Savola K, Ebeling T et al (2000) Genetic, autoimmune, and clinical characteristics of childhood- and adult-onset type 1 diabetes