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[DOI] [PubMed] [Google Scholar] 14.Muskiet MH, Tonneijck L, Smits MM, van Baar MJ, Kramer MH, Hoorn EJ, et al

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Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs