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[DOI] [PubMed] [Google Scholar] 97.Eguchi Y., Kitajima Y., Hyogo H., et al

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Understanding how semaglutide interacts with other compounds becomes important in this context

For example, some beneficiaries may use GLP-1 medications for diabetes or another approved medical indication

The superior cardioprotective effect of GLP-1 (7-36amide) relative to exendin-4 and the preservation of efficacy of GLP-1 (7-36amide) but not exendin-4 in GLP-1R KO mice suggest that some of the cardioprotective effects of GLP-1 (7-36amide) are independent of GLP-1R signaling and are potentially mediated via the DPP-4-cleaved GLP-1 metabolite GLP-1 (9-36amide) [201]