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Participants had a past-month drinking history of more than seven (for women) or more than 14 (for men) standard drinks in a week as well as two or more heavy drinking episodes (four or more drinks for women and five or more for men)
This leaves open the question that there may be some other primary effect that is yet to be determined, says Ard

Whilst these treatments are generally well-tolerated and effective, some patients report experiencing tiredness or fatigue during treatment

However, like semaglutide, retatrutide's effect on stomach emptying lessens over time, which might need a break from the drug to restore its effectiveness
The apparent desensitization half-life, which accounts for receptor recycling, was 19.27 minutes