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The absolute amount of lean mass lost is greater with GLP-1 medications primarily because the total weight loss achieved is substantially greater than with diet and exercise alone

Dawkins and Pratley note that while studies show people with obesity and type 2 diabetes experience significant weight loss on a GLP-1 agonist or dual agonist, people with type 2 diabetes experience slightly less weight loss compared with those with overweight and obesity without type 2 diabetes.1-3 Counseling Tips for RDs Despite the success of these classes of weight management medications, patients can receive anywhere from a little to a lot of information on how to optimize their use since a wide variety of clinicians, from primary care providers to obesity medicine experts, prescribe them

The modern GLP-1RA class evolved following identification of exendin-4, a GLP-1 analogue originally isolated from Gila monster venom [22]

Novo Nordisk developed an insulin degludec/liraglutide combination named Xultophy 100/3.6, or IdegLira [27]

These medications also carry a boxed warning about thyroid C-cell tumors observed in rodent studies