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Since then, liraglutide (Victoza and Saxenda, Novo Nordisk), dulaglutide (Trulicity, Eli Lilly), lixisenatide (Adlyxin, Sanofi-Aventis), semaglutide (Ozempic, Wegovy and Rybelsus, Novo Nordisk) and tirzepatide (Mounjaro and Zepbound, Eli Lilly) have been FDA approved for various indications

Preclinical evidence shows spinal GLP-1R activation attenuates bone cancer-induced allodynia via -endorphin release [24]

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