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1 Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as non-alcoholic fatty liver disease (NAFLD), has become the most prevalent chronic liver condition worldwide, affecting approximately one-third to nearly 40% of the adult population globally, with projections indicating an increase to over 55% by 2040 ( (THR-) agonist, received approval from the FDA in 2024 for the treatment of adult patients with F2-F3 MASH ( Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have gained considerable attention in recent years as promising therapeutic agents for MASLD, particularly owing to their well-established efficacy in treating type 2 diabetes mellitus (T2DM) and obesity, conditions closely implicated to MASLD pathogenesis ( This review aims to systematically summarize the mechanistic insights and clinical advances of GLP-1with dual or triple receptor agonists in MASLD treatment, thereby promoting a more profound comprehension and facilitating their application in clinical practice (Figure 1)

Adults with obesity but without type 2 diabetes received either the maximum tolerated dose of tirzepatide or the maximum tolerated dose of semaglutide

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Only a mild tongue tie and minor reductions in birth weight, AC, and liver size were noted in the neonate

For constipation: Increase fluid intake and dietary fiber gradually Consider over-the-counter osmotic laxatives like polyethylene glycol if recommended by your provider For diarrhea: Focus on hydration with electrolyte-containing fluids Over-the-counter loperamide may be appropriate for short-term use if approved by your provider Dose management strategies: If nausea is severe, discuss with your healthcare provider whether slowing the titration schedule is appropriate