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Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-Like Peptide 1 Receptor Agonists Source In both trials, after 72 weeks of treatment, patients who received Zepbound at all three dose levels experienced a statistically significant reduction in body weight compared to those who received placebo, and greater proportions of patients who received Zepbound achieved at least 5% weight reduction compared to placebo

1 dicembre 2022;257:113967

The mean duration of diabetes was 15 years

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As previously reported 20 , DIO wild-type mice fed on the high-fat diet displayed impaired glucose tolerance (Fig