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Tirzepatide, with its dual GLP-1 and GIP action, seems to show the highest weight loss potential, though it is still under evaluation

Over a five-year period, cohort A demonstrated a statistically significant increased risk of NAION (risk difference 0.022%, 95% CI 0.01%-0.034%

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In addition to endothelial expression, GLP-1R expression has been reported in various types of smooth muscle, including vascular smooth muscle, and their activation has been linked to vasodilation and increase in blood flow 6471

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