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There may be difficulties in having to refrigerate the injectable versions

Nature Communications 11(1):5781

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While all the thus far discussed studies examined the effects of GLP-1 signal reception (by exogenous GLP-1 or analog application), very few studies assessed the effects of potential endogenous GLP-1 release in both sexes

Mild redness or small bruises can happen occasionally after injections and often improve within a few days