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The STEP UP T2D trial showed that weekly semaglutide 7.2 mg led to a 13.2% weight loss vs 3.9% with placebo in adults with obesity and T2D

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After numerous manipulations on candidate molecules, one was arrived at that acted as a non-peptide GLP-1 agonist and was given the name orforglipron. Now came the next challenge

Here's some insight into Metformin and GLP-1 blockers, as discussed on the Huberman Lab