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Adequate hydration (at least 2-3 liters daily), fiber supplementation, and magnesium citrate at bedtime are the first-line approaches

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PlexusDx recommends selecting a new site each week, moving to a different anatomical location while maintaining at least one inch of distance from previous injection points

Acknowledgements Research was supported by the Research & Innovation Foundation of CyprusExcellence Hubs 2021 (EXCELLENCE/0421/0543) grant to P.Z., with A.O
