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Semaglutide treatment improves coverage of astrocytes in the cortical and hippocampal capillaries of animals with metabolic syndrome Immunohistochemical analysis allowed the evaluation of vessel coverage by astrocytes on the cerebral microcirculation, which is an essential feature of the neurovascular unit and blood brain barrier (BBB) integrity

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This dose-dependent increase between the 12.5 and 25 mg doses is also evidenced in the significant increase in the maximum concentration and AUC when the dose was increased from 12.5 to 25 mg (data not shown)