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Stopping cold often leads to gradual rebound, which is consistent with how all incretin therapies behave

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[15] [1] Zepbound is not recommended during pregnancy and should be discontinued if pregnancy occurs

The concurrent increase in both presynaptic VGLUT and postsynaptic PSD95, NMDA, and AMPA markers suggests an overall facilitation of excitatory synaptic drive, further supporting the transition of pain