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A comprehensive meta-analysis published in 2017 examining data from over 60,000 patients found no significant increase in pancreatic cancer risk associated with GLP-1 receptor agonist use

in 1984 of leptin (45), a peripheral active appetite inhibiting hormone produced by adipocytes and acting both via specific receptor (Ob-R) on afferent vagal nerves and directly on ARC neurons enhancing satiety, raised a hope in progress in obesity therapy (44)

Antibiotics are rarely indicated for uncomplicated food poisoning and should only be prescribed following appropriate clinical assessment

Cyclic vomiting syndrome (CVS), defined as recurrent episodic episodes of nausea and vomiting, should also be considered during the patient history-taking

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