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Description
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However, further research is needed to fully understand how these therapies exert their effect on body weight and in the last section we cover open questions about the potential mechanisms of multiagonist drugs, and the understanding of how gutbrain communication can be leveraged to achieve sustained body weight loss without adverse effects.

Looking ahead, the influence of US policy and Most Favoured Nation (international reference) pricing will remain a central trend that shaped obesity care in 2025 and will continue to do so into 2026 and beyond

Four study groups were established: all GLP-1RA users, SGLT2i users, insulin users and other glucose-lowering agent users (miscellany group)
