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Upadhyay, P

Effect of laparoscopic sleeve gastrectomy vs Roux-en-Y gastric bypass on weight loss, comorbidities, and reflux at 10 years in adult patients with obesity: the SLEEVEPASS randomized clinical trial

Although the pathophysiology of PBH is only partially understood, the excess postprandial insulin exposure in PBH patients is likely driven by accelerated nutrient absorption kinetics and stimulation of insulinotropic gut factors such as glucagon-like peptide-1 (GLP-1) because of the altered gastrointestinal anatomy (10)

However, as with other novel obesity drugs, Mazdutide must overcome certain challenges, such as optimizing dose-escalation strategies to reduce dropout rates due to adverse events, and ensuring consistent and sustained efficacy in larger scale clinical studies
