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For a long time, the manifestation of depressive symptoms has been also associated with the deficits in neurotrophic factor action in the brain [51], especially highlighting the role of diminished brain-derived neurotrophic factor (BDNF) signaling as important for the pathogenesis of this mental disorder [52]

These successes are even more pronounced in those treated with tirzepatide, with nearly 60% of patients losing 20% of their weight and nearly 40% losing even more than 25% of their initial weight (Figure 6B)

Effect of oral semaglutide on cardiovascular parameters and their mechanisms in patients with type 2 diabetes: rationale and design of the semaglutide anti-atherosclerotic mechanisms of action study (SAMAS)

doi:10.1016/j.cmet.2022.07.013

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