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Severe gastroparesis cases requiring feeding tubes or permanent dietary restrictions may settle in the $400,000 to $700,000 range, while NAION vision loss claims involving permanent blindness could exceed $1 million due to lifetime disability

Acknowledgements The authors thank the FILM Facility, Imperial College London for technical support on microscopy experiments and microscopy data analysis, and Prof Mark Sansom and Dr Wanling Song, Dept Biochemistry, University of Oxford, for assistance with the use of PyLipID for the GLP-1R-cholesterol binding site analysis

It is useful but not universally available and should be interpreted in clinical context

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Semaglutide (Ozempic, Wegovy, Rybelsus): A specific type of GLP-1 receptor agonist that has a 94% similarity to human GLP-1 but is designed to last much longer in the body, requiring less frequent dosing