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This suggests caffeine contributes to but does not entirely explain coffees laxative properties

doi: 10.1136/bmj.1.5794.199 [DOI] [PMC free article] [PubMed] [Google Scholar] 123

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You might experience mild nausea or stomach upset for one to two weeks as your body adjusts, though some people notice no difference
Mucoadhesive formulations can extend this residence time
