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bmjopen-2023-083550supp001.pdf (228.5KB, pdf) Pregnancy outcomes Table 2 presents the proportions of offspring with major birth defects in pregnancies exposed to GLP1-RA agonists, the reference group with diabetes and the overweight/obese reference group

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Therefore, it is possible that preservation of TCF7L2 expression could lead to reduce the atherosclerosis through the increase of GLP-1 receptor expression and decrease of inflammation process, although further evaluation would be necessary to demonstrate this point

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Another possibility of the direct effects of GLP-1 and ghrelin in the brain has been proposed since both peptides cross the brain blood barrier 25,35