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This systematic review provides a comprehensive assessment of semaglutides safety profile, with a focus on gastrointestinal adverse events and a low incidence of thyroid cancer

Clinicians should discuss long-term plans, expected benefits, and financial options to align treatment with patient priorities

However, these molecular mechanisms need to be further elucidated (8)

Novo Nordisk has added ileus to the Postmarketing Experience section of the Wegovy label under Gastrointestinal Disorders. In October 2025, Severe Gastrointestinal Adverse Reactions was added to the WARNING AND PRECAUTIONS section of the label

The anabolic effects of GIP enhance both the postprandial glucose and lipid buffering capacity of white adipose tissue and prevent ectopic fat deposition in visceral organs (179, 180)