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Months 1-2: Survival Mode Whats happening: Initial side effects peak during weeks 2-8

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What works during semaglutide therapy may not be optimal during tirzepatide therapy, and vice versa

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Macronutrient composition is the primary driver of GLP-1 release

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Expect administrative friction: prior authorizations, documentation of prior weight-loss efforts, or step-therapy requirements that delay access

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Our results indicated a no observed adverse effect level (NOAEL) of 2 nmol/kg/day for Ex-4 and a maximal tolerated dose (MTD) of 20 nmol/kg/day

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