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doi: 10.1056/NEJMoa2206038 47 WillardFSDourosJDGabeMBShowalterADWainscottDBSuterTMet al

Incorporating information about the newer GLP-1 RAs, additional head-to-head studies suggest similar A1C reductions between lixisenatide and exenatide twice daily while showing more weight loss with exenatide twice daily and less GI AEs with lixisenatide [Rosenstock et al

References New England Journal of Medicine

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In a statement, Regeneron revealed that the combination was unable to show a statistically significant improvement in median progression-free survival (PFS) compared to Keytruda, although, there was a numerical extension of 5.1 months with the highest dose 11.5 months versus 6.4 months which was not far off the threshold for significance