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Semaglutide does not directly lower cholesterol like a statin, but emerging research shows modest improvements in lipid profilesprimarily through weight loss and improved insulin sensitivity rather than a direct pharmacologic effect on cholesterol synthesis

Mechanistically, its active compounds, particularly withaferin A, are known to inhibit the master inflammatory transcription factor NF-B by blocking the activation of its upstream kinase, IKK (Heyninck et al

Also Read: The Untold Truth About Calories & Weight Loss Long-Term Side Effects of Ozempic Semaglutide While the short-term side effects of Ozempic Semaglutide tend to be mild and manageable, there are also some long-term side effects to be aware of

Clinical trials of semaglutide show that gastrointestinal side effects (including bloating) occur in 20-40% of patients early in treatment but resolve within 8-12 weeks in the majority

Dulaglutide is a similar medication to semaglutide and is in the same group of medications - a GLP-1 agonist