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There are also concerns regarding potential drug-interactions and a reduction in long-term efficacy due to tachyphylaxis [73]

It means a 0.25mg weekly injection delivers more systemic semaglutide than a 1mg daily sublingual dose in many cases

Q: What should I do to prepare for the July 1 launch

This reflects the state of play as of early 2026: States that cover GLP-1s for obesity treatment (fee-for-service): Arkansas, Colorado, Connecticut, Delaware, Illinois, Louisiana, Massachusetts, Minnesota, New Mexico, New York, Oregon, Virginia, Washington approximately 13 states total as of January 2026

For the 129 FEHB plans available in 2025 and 2026, self-only premiums will decrease in 23 plans, increase below the 12.3% average in 57 plans, and increase above the average in 49 plans