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13 GLP-1 RA cardiovascular outcome trials 29 and head-to-head studies, 1529 with a follow-up range of 0.55.4 years, have documented that GLP-1 RAs increase heart rate by 0.15.7 b.p.m., with an average increase of 2.4 b.p.m

Dry mouth tends to be dose-dependent, meaning higher doses produce more pronounced symptoms

Hypertension and dyslipidaemia were more frequently reported in the GLP1-RA exposed and in the reference group with diabetes

There is also reduced cardiovascular death, heart attack, stroke, chronic kidney disease in diabetics, and cravings in substance abuse disorders [16-18]

Eli Lilly must first compile a comprehensive New Drug Application containing all Phase 1, 2, and 3 trial data, manufacturing specifications, proposed labeling, and safety analyses