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Description
Talk to your provider if side effects feel intense after stopping

Sustained success depends on adequate protein, resistance training to preserve muscle, and long-term adherence

Another 2025 review in the European Journal of Medical Research looked at berberine's anti-obesity impact and found that several human and animal studies linked the compound with weight loss

doi: 10.3390/biomedicines11030690

Retatrutide achieved up to 24.2% body weight reduction over 48 weeks in the Phase 2 trial published in the New England Journal of Medicine , which involved adults with obesity but without diabetes
