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Patients with insulin resistance may benefit from earlier appetite suppression (injecting before high-calorie days), while those with metabolic flexibility may tolerate flexible timing

Scientists compared data from two groups of women: those with diabetes, obesity, or both who were taking a GLP-1, and women with the same conditions who were taking some other type of diabetes medication

Retatrutide is still investigational it's being tested in clinical trials and has not been approved by the FDA or other major regulators

Oxidant stress has been implicated as a possible mechanism of pancreatitis

doi: 10.1186/s12902-020-0542-5