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A phase 2 clinical trial, published in The New England Journal of Medicine, included 338 adults with a body mass index (BMI) of 30 or greater, or a BMI between 27 and 30, with at least one weight-related comorbidity to assess the efficacy and benefits of retatrutide

Cardiovascular outcomes and other key takeaways Overall, the authors found that all six OMMs were associated with significant improvements in weight loss compared to a placebo