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Efficacy and safety of canagliflozin as add-on therapy to a glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: A 52-week, open-label, phase IV study

[DOI] [PMC free article] [PubMed] [Google Scholar] 638.Yamamoto H., Lee C.E., Marcus J.N., Williams T.D., Overton J.M., Lopez M.E

Notably, the US FDA submission documents for tirzepatide include predictions of DDIs mediated by delayed gastric emptying using PBPK modeling, rather than conducting clinical DDI studies for certain drugs (Table 6).58 PBPK modeling is a mathematical approach that uses differential equations to predict pharmacokinetics in humans and other species