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Centrally Mediated Satiety (The Brain Connection) GLP-1 is capable of crossing the blood-brain barrier or signaling via the vagus nerve to reach the hypothalamus, the brains control center

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As tirzepatide is a relatively new medication whose side effect profile has yet to be fully characterized, clinicians should be aware of this rare yet potentially fatal complication. Although GLP-1 receptor agonists show impressive efficacy and favorable side effect profiles, it is necessary that we determine all risks and side effects, particularly rare ones, to minimize chances of poor outcomes, says the papers first author Eli J

GLP-1 receptors are distributed across the hypothalamus, brainstem, reward centers, and memory regions, influencing hunger signals, food preferences, and potentially cognitive function