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doi: 10.1210/jc.2011-3172 34 GregoryJMSmithTJSlaughterJCMasonHRHugheyCCSmithMSet al

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Upon activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), berberine enhances insulin sensitivity, reduces hepatic glucose output, and has been shown in animal models to increase GLP-1 secretion, although this mechanism has not yet been confirmed in large human trials

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