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No adverse effects on male or female fertility were observed in rats at doses up to 100 mg/kg (approximately 4 to 8 times male and female MRHD exposures of phentermine and topiramate extended-release based on AUC)

For anyone concerned about maintaining muscle during GLP-1 therapy, combining medication with adequate protein intake and resistance training is essential regardless of which medication is used

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The drug has also been shown to reduce the risk of heart attack, stroke, and death in those with cardiovascular disease by 20 percent

Per the company's safety information, the most common side effects are gastrointestinal - nausea, vomiting, diarrhea, constipation, bloating, and decreased appetite