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Optimization of the Caco-2 permeability assay to screen drug compounds for intestinal absorption and efflux
Failure to account for these sources of variation conflates genuinely unresponsive patients with those who receive inadequate formulation exposure or are otherwise mismatched to the intervention

Chronic stress can disrupt appetite regulation in the brain: Our brains are designed to receive hunger and satiety cues from the body and our environment, like a grumbling stomach or low blood sugar levels

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