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In a third study, Julio Rosenstock, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues found that the mean HbA1c reductions were significantly greater with cagrilintide-semaglutide (2.4 mg each and 1.0 mg each: 2.33 and 2.10 percent, respectively) versus placebo (0.66 percent) at week 40 in 274 adults with type 2 diabetes using basal insulin."These findings support a potential new therapeutic tool to effectively improve HbA1c levels well below 7 percent in such a challenging population," Rosenstock said in a statement.Several authors from all three studies disclosed ties to biopharmaceutical companies, including Novo Nordisk, which is developing cagrilintide and funded the studies.Abstract/Full Text - Aroda (subscription or payment may be required)Abstract/Full Text - Buso (subscription or payment may be required)Abstract/Full Text - Rosenstock (subscription or payment may be required)More Information.Sign up for our weekly HealthDay newsletter

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genetic variation in peptide pathways determines individual medication response

Its not clear whether the same effect occurs in humans, and large reviews of human data from 2024 to 2025 have not shown an increased risk, but the family-history exclusion remains in place across all GLP-1 SmPCs