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Sitagliptin, the first developed inhibitor, has a triazolopiperazine structure, while vildagliptin and saxagliptin have a cyanopyrrolidine structure

As they have different mechanisms of action, they can act on various aspects of glucose regulation and possibly offer a more comprehensive approach to blood sugar control

Repeated cycles of initiation, interruption and re-initiation of these drugs might induce body weight and HbA 1c fluctuations two risk factors for cardiovascular and microvascular events

GLP-1 receptor agonists have demonstrated unique properties beyond glucose regulation

Oral administration of corn zein hydrolysate stimulates GLP-1 and GIP secretion and improves glucose tolerance in male normal rats and Goto-Kakizaki rats