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Peer review Peer review information Nature Communications thanks Luca Chiovato and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

GLP-1 Mechanism and Clinical Evidence for Weight Loss Semaglutide and other GLP-1 receptor agonists work by mimicking glucagon-like peptide-1, a hormone that regulates appetite and blood glucose

The introductory dose is essential for safe adaptation

Letrozole, anastrozole and exemestane are third generation AIs and often decrease circulating oestrogen to undetectable levels 12 thereby reducing tumour proliferation and growth 13