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Schuler MS, Rose S

Why This Program Matters For many Medicare beneficiaries, cost has been the primary obstacle to accessing GLP-1 medications

Patent extensions and additional filings for new uses can extend protection beyond the primary expiration date, creating a complex timeline that varies by compound and region

Many GLP-1 patients feel these after eating half a plate

Using the SNAP-tag system, in which the GLP-1R N-terminus contains a small genetically encoded tag to allow specific labeling of surface receptors, we measured the dose responses for the agonist-induced cell surface loss of human GLP-1R in CHO-K1 cells, identifying the analogs with different net internalization efficacy than the reference compound exendin-4 (Supplementary Fig