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Description
Several plant extracts have emerged as promising candidates in enhancing GLP-1 activity or mimicking its metabolic benefits

[10] Kunutsor SK, et al
Hausner, H., Derving Karsbl, J., Holst, A

The glucagon-like peptide-1 receptor agonist reduces inflammation and bloodbrain barrier breakdown in an astrocyte-dependent manner in experimental stroke

Thus, clinical trials are needed to establish the benefits/risk profile in HF, considering that no properly designed, HF-specific randomised clinical trials have been completed with GLP-1 RAs in any of the HF phenotypes