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The current evidence base regarding tirzepatide use specifically in patients with multiple sclerosis is extremely limited , as MS patients were not systematically studied as a distinct subgroup in pivotal clinical trials

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Tirzepatide is already approved and available through proper medical channels

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Our survey found that over 75% of health plans and over 50% of employers are moderately or very concerned about off-label use, but awareness of how much current spend is off-label is notably lower: nearly half of employers and a quarter of health plans are unsure

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Cash-pay options become primary

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Mice were kept in individual ventilated cages

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