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Beyond weight outcomes, the Phase 2 obesity trial also reported improvements in several cardiometabolic markers, including: Reductions in waist circumference Improvements in fasting glucose and insulin sensitivity Favourable changes in blood pressure and lipid profiles Phase 3 trials understood to form part of the TRIUMPH programme are now underway, evaluating retatrutide in broader populations including people with type 2 diabetes and cardiovascular disease

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, et al

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Several mechanisms could theoretically explain respiratory symptoms in patients taking Mounjaro , though none are definitively established: Gastro-oesophageal reflux disease (GORD) : The delayed gastric emptying caused by tirzepatide (noted in the SmPC) may theoretically exacerbate reflux symptoms in susceptible individuals, potentially leading to chronic cough through aspiration or irritation of the airways [1] Allergic or hypersensitivity reactions : Though uncommon, any medication can potentially trigger allergic responses, which may include respiratory manifestations Coincidental respiratory infections : Patients may develop upper respiratory tract infections unrelated to their diabetes medication It is crucial to consider alternative explanations for cough in patients taking Mounjaro

4 The 2024 European Society of Cardiology guidelines manage AF using an approach called AF-CARE