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Wang T, Hong JL, Gower EW, et al

Adverse effects include GI symptoms, gallbladder events, rare pancreatitis, and boxed thyroid C-cell tumor warning based on rodent data, and avoid in MTC/MEN2 [9,11]

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Of note, a recent meta-analysis encompassing those clinical trials focused on the cardiovascular safety of GLP-1 RAs found significant reductions in MACE3 (a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke), hospitalization for heart failure and progression of chronic kidney disease [8]