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Starting low and increasing gradually helps manage this
doi: 10.2337/dc12-2006 77 RosenstockJRaccahDKornyiLMaffeiLBokaGMiossecPet al

Tirzepatide dosing should follow FDA-approved protocols: initiate at 2.5 mg subcutaneously once weekly for four weeks, then increase to 5 mg weekly

Some recommend dropping back one dose level for safety, then returning to your previous dose if tolerated well

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