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NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China
It was designed to have potent activity on both the GLP-1 and GIP receptors but with minimal to no -arrestin recruitment on either receptor
Pharmacological exploitation of the incretin axis gave rise to GLP-1 receptor agonists (GLP-1RA) and dipeptidyl-peptidase-4 inhibitors (DPP-4i), the latter preventing rapid enzymatic degradation of native incretins [7]
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