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Women with Lipedema often experience: Chronic low-grade inflammation Pain or tenderness in the legs Hormonal sensitivity Fatigue or brain fog Swelling, heaviness, or fluid retention Difficulty losing fat in affected areas These challenges are not caused by lifestyle choices, and Lipedema is not obesity

These effects may involve oxytocin signalling on vagal afferents and contribute to the negative energy balance of central GLP1 (Brierley et al., 2021

The next scheduled catalyst is earnings: Hims plans to report Q4 and full-year 2025 results after the close on February 23, 2026, followed by a conference call

In absolute terms, that was ~15 kg weight loss on semaglutide vs ~2.5 kg on placebo an unprecedented result for a medication ( [12] )

However, the associated hair loss can be dramatic and distressing